They were given Pycnogenolfor a period of 10 days. Pycnogenol effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women [Abstract]. In a double-blind, placebo-controlled, randomized, crossover study, 50 patients with erectile dysfunction (ED) were treated with either L-arginine plus Pycnogenol or placebo for a month. Dr. Eric L. Zielinski is a sought-after natural . 2005-2023 Healthline Media a Red Ventures Company. Note that the numbers in parentheses (1, 2, etc.) All included participants had subclinical cognitive impairment, which looks like typical brain fog [22]. L-arginine is more effective when paired with L-citrulline or pycnogenol to combat erectile dysfunction and improve exercise performance. Commonly called arthritis, osteoarthritis is caused when the cartilage on your joints begins to wear down. Pine bark extract is composed of 80% to 85% proanthocyanidins, the monomers catechin and taxifolin (5%), and phenolic acids, including derivatives of benzoic and cinnamic acids (2% to 4%). In 24 people with early eye damage from diabetes, Pycnogenol improved vision, reduced eye swelling, and improved circulation in the eye after 2 months. The goal of this study was to evaluate if Pycnogenol could prevent deep venous thrombosis (DVT) and superficial vein thrombosis (SVT) in eight-hour flights in 196 subjects at risk of these conditions. Pycnogenol (125 mg/day) had the same effects in another study of 48 people with diabetes and high blood pressure. Vinpocetine is used to increase brain circulation, alertness, cognitive function, concentration, and memory, as well as to lower inflammation and oxidative stress.This article will explore vinpocetine's history, how it works, its potential benefits, and any possible safety issues . Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. It may cause side effects such as: Dizziness. Align your health hacks with your genes for optimal health & cognitive function. Pycnogenol improved symptoms, circulation, and reduced complications in 156 people with deep vein thrombosis (blot clots in deep leg veins) in a 12-month study. Pycnogenol is the leading ingredient in Isotonix OPC-3, Market America's best-. A high number signals high blood pressure. Herbal supplements are not regulated by the Food and Drug Administration (FDA), so they may not be up to the same safety standards as medications that have gone through clinical testing and drug trials. In a study of 50 overweight people, a combination product (Pycnogenol, Madeglucyl, and starches called Glucaffect) reduced weight, BMI, blood glucose, and HbA1C after 8 weeks [30]. A 2011 study by Dr. G. Belcaro concluded, " Pycnogenol administration was effective for better control of signs and symptoms of allergic asthma and reduced the need for medication". Unlike drug manufacturers, the makers of supplements dont have to show their products are safe or effective before selling them on the market. Pycnogenol may help with other conditions as well. Dizziness. 7. Placebo capsules were given to control subjects at the same times. Pycnogenol, an extract of French maritime pine bark, helps the body fight normal aging by supporting vascular health and healthy circulation. Some pycnogenol supplements are mixed with other antioxidants, such as vitamin C. Pine bark extracts other than pycnogenol are also sold. It can then lead to heart problems like stroke or heart attack. Rating: 100%. Organika Pycnogenol 50mg 50 Tablets . Dr. Steven Lamm did a great job at explaining the new benefits of pycnogenol. The remaining compounds are phenolic acids, which may also have antioxidant activity [1, 2]. Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. Pycnogenol also potentially improved cognitive function in 78 people with mild cognitive impairment. Two studies illustrate the possibilities: One was a randomized, double-blind, placebo-controlled, crossover study in which 26 asthmatic patients were given either a maximum of 200 mg a day of Pycnogenol or placebo for the first period of four weeks and then crossed over to the alternate treatment for the next four weeks. A study of 66 healthy adults found that Pycnogenol may reduce the number of leg cramps experienced [11]. Learn more about how to get even skin tone. A popular variety is the pinus maritime or the maritime pine that grows exclusively along the coast of southwest France. Disease of the retina in the eye. $47.99. In one study, 10 patients were treated with placebo and 30 patients were treated with Pycnogenol (100 mg twice or three times daily for two months). Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. In another trial, 30 people with type 2 diabetes received a range of pycnogenol doses. Pycnogenol was gradually increased to 120 mg/day over this time period, while the l-arginine was maintained at 1.7 g/day throughout. Your email address will not be published. In the study, women taking Pycnogenol were more satisfied and compliant to the regimen [24]. Pycnogenol is officially extracted from the French maritime pine (Pinus pinaster), which grows in the southwest coast of France. In a study of 72 children undergoing cancer chemotherapy, Pycnogenol reduced painful mouth ulcers, both alone and in combination with vitamin E [79]. The staff there can often answer any questions you have and give you more information about specific brands. Tongkat ali is an herbal remedy suggested to treat various ailments, including low testosterone and male infertility. A clinical trial of 57 ADHD children found that daily Pycnogenol (1 mg/kg) for one month may reduce hyperactivity symptoms. Its quality is specified in the United States Pharmacopeia [3]. Studies have found that nattokinase thins the blood and dissolves accumulated solids in it. If youre native to Oregon, you likely know all about marionberries. 5. In a clinical trial of 40 men with erectile dysfunction, 92.5% of the men on this combination regained normal erections after 3 months. It seems to lower blood pressure and improve blood flow to the legs. Based on another study of 6 trained and 7 untrained people, an antioxidant combination product containing Pycnogenol (Lactaway) may increase endurance. Pine bark extract is usually taken by mouth in capsule form. It may cause side effects such as: Risks. Clinical research suggests that Pycnogenol is possibly effective for improving athletic performance. Fundukian, L.J. Diabetic retinopathy is a type of eye injury caused by complications from diabetes. A study of 58 people with high blood pressure suggests that even lower doses (100 mg/day) may improve blood vessel health and reduce markers of high blood pressure (endothelin-1) after 12 weeks. However, healthy people are not immune and can also develop mild infections, in particular after being in improperly chlorinated hot tubs or swimming pools. Help your body fight the effects of normal aging. That said, there are some instances where this extract may possibly be effective. is a clickable link to peer-reviewed scientific studies. 40 years of research has been dedicated to establishing the safety of Pycnogenol and its benefits for human health. Chewing gum with Pycnogenol (2.5 mg/piece) for 4 weeks reduced bad breath and mouth bacteria in a trial of 22 people [57]. These antioxidants scavenge those damaging free radicals in an effort to eliminate them, ultimately preventing disease. Pycnogenol acts as a sustained-release formulation. Required fields are marked *. WebMD does not provide medical advice, diagnosis or treatment. So it may not be safe for people with immune disorders, such as: It's not known if pycnogenol is safe for children or for women who are pregnant or breastfeeding. More specifically, because it strengthens the capillaries in the retina, Mirtogenol can help prevent retinopathy. It has many health benefits, and may help protect against several chronic conditions. Sort By. A 2017 review reported on the many benefits of using pine bark extract to reduce the effects of aging on skin. In another trial, a combination supplement (Pycnogenol 60 mg/day, L-arginine 690 mg/day and aspartic acid 552 mg/day) improved erectile dysfunction and sexual satisfaction in men after 8 weeks. (1, 2). One way to add some extra flavor and nutrients to your day is by adding prune juice to your diet. For asthma in children: 1 milligram per pound of body weight given in two divided doses. ", Journal of Medicinal Food: "Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol. Score one for diabetes control and fewer risk factors for the heart. But two months ago, erectile dysfunction health food with the help of the Divine Tool Alliance, the price of all materials related to the puppet mechanism was raised by 20 erectile dysfunction health food 30 , and the price of selling the puppet was reduced by 10. Pycnogenol: A miracle component in reducing ageing and skin disorders. Risks. However, it's always a good idea to start with a low dose so you can monitor how your body responds. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is standardized to contain 65-75% procyanidins, a class of polyphenols and flavonoids like those found in blueberries, wine, grape skin, citrus, and cocoa. In some people lung inflammation is caused by leukotrienes chemicals that are released by the body after a person encounters allergens. In another study, Pycnogenol increased glutathione levels and total antioxidants after a month in children with ADHD [42, 43]. but is for informational and educational purposes alone. chronic anal fissure may take more than 6 weeks to heal. In 7 volunteers, Pycnogenol (300 mg) for 5 days may reduce the activity of a crucial inflammatory gene (NF-B) [53]. However, this was a relatively small study, so larger ones are needed to fully understand pine bark extracts role in these findings. Add to Cart. 7. These wounds occur most frequently in hospitals or in those with weakened immune systems, such as after surgery. A study of 147 people found that pycnogenol (100 mg/day) may improve running, push-ups, and sit-ups endurance in recreational athletes over an 8-week training program. There is limited evidence that it could be used in treating Attention Deficit Hyperactivity Disorder (ADHD). Not bad. Another clinical trial of 76 people with allergic asthma also suggests that Pycnogenol may reduce IgE antibodies and asthma symptoms [18, 16]. It also provides powerful antioxidant protection and helps inhibit inflammatory factors to support. According to a study of 11 patients with lupus, pycnogenol may reduce symptoms, inflammation, and oxidative stress [54]. Mental function. In addition to general healthy eating, some specific vitamins and minerals may help improve ADHD. This study adds to a body of research showing the benefits of Pycnogenol for improving circulation and blood flow, strengthening the vascular system and managing cholesterol. Known for its antioxidant properties, Pycnogenol offers a wide range of potential health benefits. Comment * document.getElementById("comment").setAttribute( "id", "a79cdfe7a30d8f84d45d97f833c00b8c" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. In those treated with Pycnogenol, the edema score was increased by 17.9% versus an increase of 58.3% in the control group. Pycnogenol; Pycnogenol. A study of 32 people with heart failure lasting 12 weeks suggests that a combination of Pycnogenol with CoQ10 (PycnoQ10) may improve blood pressure, heart function, edema, and capacity for physical activity [40]. Remember to speak with a doctor before taking Pycnogenol. In another study, 61 children with ADHD were given one mg per kg/day of Pycnogenol or placebo over four weeks. ( 1) 2. Pycnogenol in metabolic syndrome and related disorders [Abstract]. This supplement possibly activates the immune system. A new peer-reviewed study, published in the Bratislava Medical Journal, shows that daily supplementation with the natural antioxidant, Pycnogenol, a French maritime pine bark extract, can improve the symptoms of ED.. In one study, people with high blood pressure were examined to see how the supplement impacted their blood pressure. Pycnogenol is a compound of natural chemicals. Pycnogenol is similar to grape seed extract and cocoa polyphenols as those are the three most common . She is a strong advocate of integrating scientific knowledge and holistic medicine. According to research, Pycnogenol may have a multitude of health benefits, which are likely due to this extracts antioxidant and anti-inflammatory properties. Dr. Drew explains the benefits of probiotics for the gut microbiome and talks about the rise of leaky gut, and Dr. Steve shares how emotional stress can have real physical effects on the heart. The specific tree from which the bark is extracted is called a maritime pine. (2012). Pycnogenol can help control blood pressure, which helps improve overall heart health. Pycnogenol is known under different names in some countries, such as Oligopin, and Flavangenol in Japan [4, 5]. Finally, research suggests that Pycnogenol may improve triathlon time while possibly reducing cramps and post-running pain [10]. Abdominal pain was by far the most . Studies were conducted in Turkey on subjects who underwent abdominal surgery to determine if the pine bark extract could help reduce the inflammation. Chestnut seed extract did not do as well. PQQ (pyrroloquinoline quinone), also called methoxatin, is a vitamin-like compound that exists naturally in soil and a variety of foods, including spinach, kiwi, soybeans, and human breastmilk . One study suggests that Pycnogenol has no effect when given just 3 weeks beforehand, as it possibly requires a lag time to stabilize the immune response [17]. (2017). . Pycnogenol (150 mg/day) reduced pain in a study of 100 people with osteoarthritis after 3 months. (2013). However, it can also be used topically. A trial of children with ADHD found that Pycnogenol may improve attention, possibly by increasing the total antioxidant status and reducing DNA damage. Studies have shown that the tree bark can help decrease common symptoms including hot flashes, mood swings, irregular periods, and others. The same study showed that a single, 200-mg Pycnogenol dose remained effective over six days in preventing cigarette-induced enhanced platelet aggregation. Procyanidins are chain-like structures consisted of catechins similar to some found in green tea (the green tea catechins that do not have 'gallate' in their names). Let us discuss them in detail below. Therefore, those who have autoimmune conditions could see their symptoms increase after taking it., Since Pycnogenol is used for so many conditions, doses can vary. Speak with your doctor before supplementing. painful urination. Pycnogenol is a patented formulation of Pine Bark Extract which is standardized to 65-75% Procyanidin compounds by weight. Pycnogenol lotions applied postirradiation reduced this immunosuppression to 22% (0.05% Pycnogenol) and 13% (0.1% Pycnogenol). Pycnogenol is thought to be an antioxidant that helps protect cells from damage. 10 Ways to Control Blood Sugar without Medication, Pycnogenol (French Maritime Pine Bark Extract): 12 Benefits According to Studies, Reduces leaky blood vessels by making the wall proteins (collagen, elastin) more resistant to damage, Helps maintain high vitamin C and E blood levels for their antioxidant effects, Inhibits platelet aggregation like low-dose aspirin, Reduces hardening in the arteries by increasing nitric oxide production in blood vessels, leading to greater dilatation, Counteracts the damaging effects of ultraviolet radiation, Stimulates the immune system by boosting T and B cell functions, Protects brain cells from toxic chemicals. Joe Cohen flipped the script on conventional and alternative medicine and it worked. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. The antibacterial activity was assessed indicating that the essential oil of pine bark, specifically the proanthocyanidins, were effective against P. aeruginosa, significantly inhibiting its growth. ( 4) Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. Pycnogenol is the registered trademark brand name of French maritime pine bark extract. According to some researchers, Pycnogenol may lower blood pressure by relaxing blood vessels, reducing free radicals, and lowering inflammation. ", Natural Medicines Comprehensive Database web site: "Pycnogenol.". Researchers suggest that it may epigenetically turn off genes responsible for joint damage (ADAMTS) as well as reduce inflammation enzymes (MMP3) and cytokines (IL 1-beta) [47, 48]. are clickable links to these studies. Pycnogenol led to a reduction of muscle cramps from 4.8 a week to 1.3 at week four. returned. Researchers from the study suggest that low Pycnogenol dosage and short study duration may explain the lack of benefits [44]. (11, 12), While both eliminate pain, the pine bark extract is a far better choice. Pycnogenol completely normalized function. There is a seemingly growing problem with skin exposure to ultraviolet radiation and the confusion of how to get vitamin D from the sun while avoiding these skin-damaging rays. 1. The positive improvements in symptoms were greater among those taking Pycnogenol. Pycnogenol has not been found to cause these issues however, it may take a little longer the feel the relief from pain than aspirin. According to a Japanese study, the combination of Pycnogenolt and L-arginine may produce the results youre looking for, making the bedroom a much happier place. In the study, many of the participants on Pycnogenol reduced their dosage of high-blood-pressure medication (nifedipine) [37]. Grape seed extract may have heart-health benefits. The combination of L-arginine and Pycnogenol may help in erectile dysfunction by boosting nitric oxide, which potentially could improve blood flow in men [66]. Pycnogenol alleviated adverse effects in cancer patients, Pycnogenol improved working memory in older adults, Pycnogenol lowered the use of analgesic drugs in dysmenorrhea (severe menstrual pain), Pycnogenol reduced symptoms in endometriosis comparable to leuprorelin, the standard drug for this condition, Pycnogenol was found to be effective for sun-caused hyperpigmented skin, Pycnogenol reduced the inflammation in lupus patients, Pycnogenol reduced gingival bleeding and plaque formation. A randomized placebo-controlled trial of 60 children with mild-to-moderate asthma found that those who took Pycnogenol may be able to reduce or discontinue their use of rescue inhalers more often than the placebo group [15]. The standard dose appears to be 100-200 mg/day. Is Garcinia Cambogia Safe for Weight Loss? 1. Plus, it reduced total and LDL (bad) cholesterol. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. It comes from the bark of a European pine tree. It also reduced LDL cholesterol at a slightly lower dose (125 mg/day) in those with type 2 diabetes in a clinical trial of 48 people after 12 weeks. Learn about all the potential benefits of Pycnogenol and find out which ones are most supported by science. It is chronic venous insufficiency, a common disease among people who are obese or elderly and those who lead a sedentary lifestyle. Another study in 2012 showed that Pycnogenol alone, at a dose of 75 mg/day, increased skin hydration by 8% after just 6 weeks; in women with dry skin at baseline the increase was 21%. Another one of its exemplary effects is helping manage blood pressure levels. - Please read carefully and implement principles included in the Health Recovery Plan. Video: Why You Need Zinc and Where to Find It. Depending on the extraction process and the source Pinus species used (P. radiata or P. pinaster), the exact composition will vary. Traditionally, people might drink a brew made from pine bark -- rich in pycnogenol -- as a treatment. Pycnogenol French maritime pine bark extract acts as a potent blend of antioxidants, it is a natural anti-inflammatory, stimulates generation of collagen and hyaluronic acid and help with natural dilation of blood vessels by supporting production of nitric oxide. The usual recommended duration of treatment for topical application is 7 days for Pycnogenol cream and 6 weeks for Pycnogenol powder. Blood pressure is an important measure of how much blood is pumping from your heart to the rest of your body. Read More: Health Benefits of Peanut Butter. It can also be used for local application on the skin without the risk of side effects. Side effects. Results failed to show any efficacy of Pycnogenol or methylphenidate when compared to placebo. Natural Factors Pycnogenol 25mg 60 Veggie Caps. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Certain studies used combination products, so its unknown what the contribution of Pycnogenol itself was. Pycnogenol reduced foot swelling in 79% of the patients, versus one percent in the placebo group. After taking a break for one to two weeks, they can start taking it again for several weeks. A 10 week clinical trial with 30 children shows that Pycnogenol may improve symptoms of Crohns disease. A combination supplement (pycnogenol with collagen, coenzyme Q10, and other ingredients) reduced skin aging, elasticity, hydration, and tonicity in a study of 30 women [65]. For mild high blood pressure: 200 milligrams daily. Skin irritation. It also slightly decreased blood pressure and increased testosterone [67]. It also may enhance swimming, biking, and running scores in professional athletes preparing for a triathlon (at 150 mg/day). In the study, the placebo group had higher IgE antibodies to the birch allergen than those who took Pycnogenol during the allergy season [17]. Early research shows that taking it at least 5 weeks before the start of allergy season seems to lessen symptoms. In contrast, almost 20% of the participants on inhalers alone had to increase their dosage. Pycnogenol-treated patients had significant improvement in symptoms as well as a reduction in leg swelling as compared to those not receiving treatment. Pine bark extract appears to reduce the creation of free radicals, which are molecules linked to several skin conditions. Researchers suggest this effect may be due to reduced dopamine and adrenaline levels and increased glutathione levels. No side effects were noted, unlike its synthetic counterpart. Can Pycnogenol help? We don't yet know what the best dose to use is, but studies have used two 50 mg Pycnogenol capsules per day. are clickable links to medically peer-reviewed studies. From diabetes and sexual function to sports performance and beautiful skin, pine bark extract may be worth exploring to provide results youre looking to achieve. Set Ascending Direction. Research indicates that Pycnogenol provides an increase in survival performance of train athletes. High-dose Pycnogenol (360 mg/day) for 4 weeks had the same LDL-lowering benefits in another study of 40 people [32, 56]. The researchers of the study propose that pycnogenol may reduce pain and cramps during retraining and rehabilitation in people with blood vessel problems [11]. (14, 15). A clinical trial of 60 health professionals found that Pycnogenol (150 mg/day) may improve cognitive function, attention, mental performance and specific professional skills after 12 weeks. Take Helpful Supplements. But what are its health benefits? Today's Dietitian: "Pycnogenol Supplement Offers Promise for Managing a Variety of Conditions." With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. In a third study, 19 men with fertility problems were given 200 mg Pycnogenol daily for 90 days. Pycnogenol is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins . Pycnogenol seems to help with asthma and allergies. Diindolylmethane, or DIM for short, is a plant indolea plant compound with health-promoting properties. They could interact with medicines to suppress the immune system, chemotherapy drugs, and blood thinners. Both supplements are antioxidants, which have been shown to help with blood flow and erectile function. If you choose to use Pycnogenol, follow the dosage instructions on the label. The results showed that the combination of local and systemic applications of Pycnogenol were the best in terms of ulcer healing even though local application of Pycnogenol also speeded up ulcer healing. During week, five without, treatment, reduction of cramps was maintained in all three groups. A total of 40 patients with retinopathy (damage to the retina part of the eye) from diabetes and other vascular causes were enrolled in one study. Pycnogenol is the US trademarked name for an antioxidant made from Mediterranean tree bark. Pycnogenol accelerates wound healing and reduces scar formation [Abstract]. However, it is also important to see beyond the pyncogenol marketing campaign and understand the possible dangers associated with this natural supplement. A systematic review of 14 studies found that Pycnogenol gum or mouthwashes may reduce dental plaque, but the quality of evidence is low [58, 59]. Studies have been conducted to review the effects of pine bark extract on pseudomonas infectious wounds. Importantly, all studies found that Pycnogenol has to be taken at least 5 weeks before the allergy season in order to see potential benefits, with the best results in those who take it 7-8 weeks ahead. Jonathan Ritter, PharmD, PhD (Pharmacology), Small molecule antioxidants (phenolic acids, catechin, and taxifolin) are quickly absorbed and begin to act in the body within 30 min, The remaining more complex antioxidants (long chains of procyanidins) reach the gut, where your, The microbiome-produced active compounds appear in blood 6 h later and remain for at least 14 h, Pycnogenol is standardized to contain 70 5% procyanidins, which should be on the label, Pycnogenol standardization doesnt determine other major active compounds, which can vary. 11 Skin elasticity increased, and skin fatigue decreased significantly in this study as well, further lowering the wrinkling risk. But did you know that pine bark extract, like pine oil, is one of natures super antioxidants? DOI: Gulati OP. Pycnogenol (150 mg/day) reduced LDL and increased HDL cholesterol in a trial of 25 healthy people after 6 weeks [55]. If youre wondering how to get an even skin tone, there are plenty of remedies that can help. Eliminate blood clots. Pain score in the Pycnogenol-treated group was reduced by 56%, as compared to 9.6% reduction in the placebo group. The same ingredient can be found in grapeseed oil, the skin of peanuts and witch hazel bark. Headaches. Taking pine bark extract supports healthy blood pressure. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. View as: Grid List. If you are thinking of taking Pycnogenol for a serious health condition like asthma or high blood pressure, check with your doctor., People who have autoimmune conditions like multiple sclerosis or lupus should talk to their doctor before trying Pycnogenol. The 2012 study on the anti-aging benefits of Pycnogenol is commonly-cited by anti-aging supplement manufacturers.
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